Nutritional Approach Targeting Gut Microbiota in NAFLD-To Date

Area of Science:

• Hepatology
• Gastroenterology
• Microbiology

Background:

• Non-alcoholic fatty liver disease (NAFLD) affects 25% of adults globally, increasing risks for liver disease, cardiovascular issues, diabetes, and cancer.
• Gut microbiota (GM) dysbiosis is increasingly recognized as a key factor in NAFLD pathogenesis.
• GM influences critical metabolic pathways, including nutrient processing and bile acid metabolism.

Purpose of the Study:

• To review current knowledge on nutritional approaches for NAFLD treatment.
• To explore the implications of diet on gut microbiota modulation in NAFLD.
• To highlight the potential of nutritional interventions as a therapeutic tool for NAFLD.

Main Methods:

• Literature review of studies on NAFLD, gut microbiota, and nutritional interventions.
• Analysis of the role of diet in maintaining GM stability.
• Examination of the effects of probiotics, prebiotics, and bioactive dietary substances.

Main Results:

• Diet is a critical factor in GM stabilization.
• Probiotics, prebiotics, and synbiotics can reverse GM dysbiosis in NAFLD.
• Bioactive dietary substances show potential beneficial effects in NAFLD.

Conclusions:

• Nutritional therapy is a promising strategy for NAFLD management.
• Targeting GM through diet can be an essential tool for NAFLD treatment.
• Further research into nutritional interventions and GM modulation mechanisms is warranted.