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Marital idiopathic inflammatory bowel disease. Crohn's disease in a husband and wife
1Department of Medicine, University of Alberta, Edmonton, Canada.
Journal of Clinical Gastroenterology
|February 1, 1988
Insights
This study examines two spouse pairs with Crohn's disease, a type of inflammatory bowel disease. It compares these cases to previously documented instances of chronic idiopathic inflammatory bowel disease in married couples.
Area of Science:
- Gastroenterology
- Genetics
- Epidemiology
Background:
- Crohn's disease is a chronic inflammatory bowel disease (IBD) with complex etiology.
- Familial aggregation of IBD suggests a potential genetic component.
- Spousal concordance for IBD is rare but reported, prompting further investigation.
Observation:
- Presents two new cases of Crohn's disease diagnosed in a married couple.
- Compares these cases with seven previously reported instances of chronic idiopathic IBD in spouses.
- Highlights the unique occurrence of IBD within a marital dyad.
Findings:
- The occurrence of Crohn's disease in both partners of a couple is uncommon.
- Analysis of these cases alongside prior reports may offer insights into shared environmental or genetic factors.
- Further research is needed to understand the potential for non-genetic influences in IBD.
Implications:
- Understanding spousal concordance can shed light on the multifactorial nature of Crohn's disease.
- May inform future research into environmental triggers and genetic predispositions for IBD.
- Highlights the importance of considering familial and household exposures in IBD etiology.
Abstract:
Two cases of Crohn's disease in a husband and wife are described and compared with the seven previously reported cases of chronic idiopathic inflammatory bowel disease occurring in spouses.