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T helper 17 cell responses induce cardiac hypertrophy and remodeling in essential hypertension

Liangjie Xu1, Guanghua Chen1, Yi Liang1

  • 1Department of Cardiology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, China

Polish Archives of Internal Medicine
|February 11, 2021
PubMed

Insights

Elevated type 17 helper T (TH17) cells indicate cardiac remodeling in hypertension. Higher TH17 cell levels predict left ventricular hypertrophy and poorer prognosis in hypertensive patients.

Area of Science:

  • Immunology
  • Cardiology
  • Hypertension Research

Background:

  • Type 17 helper T (TH17) cell responses are implicated in cardiac remodeling due to sustained pressure overload.
  • Understanding the role of TH17 cells in hypertension is crucial for managing cardiovascular complications.

Purpose of the Study:

  • To investigate the association between TH17 cell responses and cardiac remodeling in hypertensive patients.
  • To determine the prognostic value of TH17 cell responses in predicting outcomes for individuals with hypertension.

Main Methods:

  • 187 hypertensive adults and 70 healthy controls were studied.
  • TH17 cell frequencies, fibrotic markers, and echocardiography (assessing left ventricular diastolic function) were analyzed at baseline and after 24 months.
  • Statistical analyses included ROC and logistic regression.

Main Results:

  • Hypertensive patients showed increased TH17 cell percentages, especially those with left ventricular hypertrophy (LVH).
  • TH17 cells effectively predicted LVH (AUC=0.943) and were independent predictors.
  • Higher TH17 cell levels correlated with fibrotic markers and indicated a worse prognosis.

Conclusions:

  • TH17 cell differentiation reflects cardiac hypertrophy and remodeling in response to hypertension.
  • TH17 cells may serve as a potential inflammatory marker for predicting the prognosis of hypertensive patients.
Abstract

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