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Related Experiment Video

Updated: Nov 17, 2025

Establishment of Epstein-Barr Virus Growth-transformed Lymphoblastoid Cell Lines

Establishment of Epstein-Barr Virus Growth-transformed Lymphoblastoid Cell Lines

Published on: November 8, 2011

New Kids on the Block.

Dipti M Karamchandani¹, Hazed Hammad², Runjan Chetty³

¹From the Department of Pathology, Penn State Health Milton S. Hershey Medical Center, Hershey, Pennsylvania (Karamchandani).

Archives of Pathology & Laboratory Medicine

|February 11, 2021

Summary

This summary is machine-generated.

Pathologists face new gastrointestinal foreign materials from iatrogenic agents. Accurate identification of these materials, like pharmaceutical fillers and resins, is crucial for correct diagnosis and avoiding further testing.

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Area of Science:

Gastrointestinal Pathology
Diagnostic Histology
Iatrogenic Material Identification

Background:

Pathologists increasingly encounter novel foreign materials in gastrointestinal specimens due to rising use of iatrogenic agents.
Unfamiliarity with these materials can lead to diagnostic challenges, particularly without clinical history.

Purpose of the Study:

To review the histopathologic features, clinical significance, and differential diagnoses of emerging iatrogenic agents found in GI specimens.
To cover agents including pharmaceutical fillers, submucosal lifting agents, lanthanum carbonate, hydrophilic polymers, OsmoPrep, yttrium 90 microspheres, and resins.

Main Methods:

Compilation of findings from published literature, including recent research.
Inclusion of authors' personal experiences from clinical sign-out and consult cases.

Main Results:

Detailed histopathologic characteristics of various iatrogenic agents are presented.
Clinical scenarios and diagnostic implications are discussed for each agent.

Conclusions:

Correct identification of iatrogenic agents is vital for explaining histopathologic findings and guiding further diagnoses.
Awareness of these agents, even inert ones, prevents misdiagnosis and unnecessary investigations.