RIFM fragrance ingredient safety assessment, cyclohexanol, CAS Registry Number 108-93-0

Area of Science:

• Toxicology
• Environmental Science

Background:

• Cyclohexanol is a widely used industrial chemical.
• Comprehensive safety data is essential for regulatory compliance and risk assessment.

Purpose of the Study:

• To evaluate the safety of cyclohexanol across various toxicological and environmental endpoints.
• To determine if current usage levels pose any risks to human health or ecosystems.

Main Methods:

• Genotoxicity assays, repeated dose toxicity studies, reproductive toxicity assessments.
• Evaluation of phototoxicity, skin sensitization, and local respiratory toxicity.
• Environmental safety assessment including PBT criteria and risk quotients (PEC/PNEC).

Main Results:

• Cyclohexanol demonstrated no genotoxicity.
• Margins of Exposure (MOE) >100 for repeated dose and reproductive toxicity.
• No concerns for skin sensitization, phototoxicity/photoallergenicity, or local respiratory toxicity (exposure below TTC).
• Cyclohexanol is not persistent, bioaccumulative, and toxic (PBT); risk quotients are <1.

Conclusions:

• The existing data support the safe use of cyclohexanol at current declared levels.
• Cyclohexanol presents no significant safety concerns for human health or the environment.
• The safety assessment confirms the suitability of cyclohexanol for its intended applications.