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Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria
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Bacteriophage-Delivering Hydrogels: Current Progress in Combating Antibiotic Resistant Bacterial Infection
Hyun Young Kim1, Rachel Yoon Kyung Chang1, Sandra Morales2
1Advanced Drug Delivery Group, Faculty of Medicine and Health, School of Pharmacy, The University of Sydney, Sydney, NSW 2006, Australia.
Antibiotics (Basel, Switzerland)
|February 12, 2021
Summary
Bacteriophage therapy delivered via hydrogels offers a promising alternative to antibiotics for treating resistant bacterial infections. This review explores hydrogel formulations for bone, urinary tract, and wound infections, focusing on their preparation, stability, efficacy, and safety.
Area of Science:
- Biomedical Engineering
- Infectious Diseases
- Materials Science
Background:
- Antibiotic resistance is a critical global health threat.
- Bacteriophage (phage) therapy is an emerging alternative to antibiotics.
- Hydrogels are suitable carriers for delivering biological molecules like phages.
Purpose of the Study:
- To review the formulation of phage-delivering hydrogels.
- To focus on orthopedic implant-associated bone infection, catheter-associated urinary tract infection, and trauma-associated wound infection.
- To evaluate hydrogels as phage carriers regarding preparation, stability, efficacy, and safety.
Main Methods:
- Literature review of phage-delivering hydrogel formulations.
- Analysis of preparation methods for hydrogels incorporating phages.
- Assessment of hydrogel stability, efficacy, and safety as phage carriers.
Main Results:
- Hydrogels can be effectively formulated to incorporate bacteriophages.
- Phage-delivering hydrogels show potential for treating specific infections.
- Key parameters for hydrogel formulation include preparation, stability, efficacy, and safety.
Conclusions:
- Phage-delivering hydrogels represent a viable strategy against antibiotic-resistant infections.
- Further research into hydrogel formulation is crucial for optimizing phage therapy.
- Hydrogels offer a promising platform for localized delivery of phages in clinical settings.
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