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Published on: February 27, 2016
Sirt1 Activity in the Brain: Simultaneous Effects on Energy Homeostasis and Reproduction
Stefania D'Angelo1, Elena Mele1, Federico Di Filippo2
1Department of Movement Sciences and Wellbeing, University of Naples Parthenope, 80133 Napoli, Italy.
Abstract:
Diet deeply impacts brain functions like synaptic plasticity and cognitive processes, neuroendocrine functions, reproduction and behaviour, with detrimental or protective effects on neuronal physiology and therefore consequences for health. In this respect, the activity of metabolic sensors within the brain is critical for the maintenance of health status and represents a possible therapeutic target for some diseases. This review summarizes the main activity of Sirtuin1 (Sirt1), a metabolic sensor within the brain with a focus on the link between the central control of energy homeostasis and reproduction. The possible modulation of Sirt1 by natural phytochemical compounds like polyphenols is also discussed.
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