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The elimination of spermidine from plasma in rats
A Emonds1, M van de Ven, J Hermans
1Dept. of Pharmacology, University of Leiden, The Netherlands.
Methods and Findings in Experimental and Clinical Pharmacology
|January 1, 1988
Abstract:
Infused spermidine in rats with bypassed livers was eliminated very slowly, whereas endogenous spermidine in saline-infused controls with bypassed livers increased. In the same animals endogenous putrescine plasma levels did not differ significantly between spermidine- or saline-infused animals, whereas endogenous cadaverine levels increased during spermidine infusion and decreased afterwards. It is concluded that the liver is the most important site for plasma spermidine elimination.