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Super-resolution RNA imaging using a rhodamine-binding aptamer with fast exchange kinetics

Murat Sunbul1, Jens Lackner2, Annabell Martin3

  • 1Institute of Pharmacy and Molecular Biotechnology (IPMB), Heidelberg University, Heidelberg, Germany. msunbul@uni-heidelberg.de.

Nature Biotechnology
|February 12, 2021
PubMed
Summary

We developed RhoBAST, a novel RNA aptamer for super-resolution imaging. Its fast kinetics and intermittent fluorescence allow precise visualization of RNA structures in cells without photobleaching limitations.

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