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Updated: Nov 17, 2025

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Author Spotlight: Overcoming Anti-VEGF Resistance Through Advanced Vascular Morphology Assessment in Choroidal Neovascularization
Published on: August 11, 2023
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Favourable outcome in retinal macrovessel-related choroidal neovascularization
Waseem M Al-Zamil1, Moustafa S Magliyah2
1Imam Abdulrahman Bin Faisal University, Saudi Arabia.
Summary
Congenital retinal macrovessel (CRM) is a rare vascular condition. A case report shows that aflibercept treatment can improve vision in CRM patients with choroidal nonvascular membrane (CNV).
Area of Science:
- Ophthalmology
- Vascular Biology
- Retinal Imaging
Background:
- Congenital retinal macrovessel (CRM) is a rare vascular anomaly characterized by an aberrant retinal vessel crossing the macula.
- CRMs are typically asymptomatic and discovered incidentally during funduscopic examinations.
- This condition involves abnormal blood vessel development within the retina.
Observation:
- This report details a unique case of a venous CRM.
- The patient presented with visual impairment attributed to the development of a choroidal nonvascular membrane (CNV).
- The aberrant vessel's anatomical characteristics and its association with CNV were noted.
Findings:
- Intravitreal injection of aflibercept was administered as a treatment for the CNV.
- The treatment led to a significant improvement in the patient's visual acuity.
- Anatomical assessment confirmed a favorable outcome with resolution of the CNV.
Implications:
- This case highlights a potential complication of CRM, namely CNV-induced visual impairment.
- Intravitreal aflibercept demonstrates efficacy in managing CNV associated with CRM.
- Further research may explore the long-term outcomes and optimal management strategies for CRM-related complications.
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