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Current Perspective on Nasal Delivery Systems for Chronic Rhinosinusitis
Junhu Tai1, Kijeong Lee1, Tae Hoon Kim1
1Department of Otorhinolaryngology-Head & Neck Surgery, College of Medicine, Korea University, Seoul 02841, Korea.
Pharmaceutics
|February 13, 2021
Summary
Topical nasal treatments are key for chronic rhinosinusitis. Research is exploring new agents and delivery methods to improve drug effectiveness for this upper respiratory disease.
Area of Science:
- Otorhinolaryngology
- Respiratory Medicine
- Pharmacology
Background:
- Chronic rhinosinusitis (CRS) is a prevalent upper respiratory disease.
- Topical nasal drug delivery is the primary therapeutic strategy for CRS.
- Current treatments include steroids, antibiotics, and antifungals, with ongoing research for novel agents.
Purpose of the Study:
- To review current and novel methods for nasal drug delivery in CRS management.
- To introduce recent advances and future perspectives in topical treatments for upper respiratory diseases.
Main Methods:
- Review of existing literature on chronic rhinosinusitis treatments.
- Analysis of factors influencing nasal drug delivery fluid dynamics (device, volume, compounds).
- Exploration of novel agents targeting bacterial biofilm and mucociliary clearance.
Main Results:
- Topical nasal drug delivery is crucial for CRS management.
- Nasal drug delivery efficacy is influenced by fluid dynamics, device, volume, and compounds.
- Research is advancing to improve bacterial biofilm disruption and mucociliary clearance.
Conclusions:
- Optimizing nasal drug delivery is essential for effective CRS treatment.
- Future research should focus on innovative compounds and delivery systems for upper respiratory diseases.
- Advances in fluid dynamics and agent development hold promise for improved CRS therapies.
Keywords:
chronic rhinosinusitisdrug deliveryfluid dynamicstopical treatmentupper respiratory diseasesMore Related Videos
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