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Related Experiment Video

Updated: Nov 17, 2025

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Polymerically engineered upconversion nanoparticles (UCNPs) as contrast agent for functionally modified optical

Muktesh Mohan1, Raju Poddar1

  • 1Biophotonics Lab, Department of Bioengineering, Birla Institute of Technology-Mesra, Ranchi, JH 835215, India.

Materials Science & Engineering. C, Materials for Biological Applications
|February 13, 2021
PubMed
Summary
This summary is machine-generated.

Polymerically modified upconversion nanoparticles (UCNPs) enhance bioimaging contrast in swept source optical coherence tomography (SSOCT). Polyvinylpyrrolidone-coated UCNPs demonstrated superior performance for molecular-level tissue imaging.

Keywords:
Functionalized upconversion nanoparticles (fUCNPs)NanomaterialsPolyethylene glycol (PEG)Polyvinylpyrrolidone (PVP)Scattering coefficientSwept source optical coherence tomography (SSOCT)

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Area of Science:

  • Nanotechnology
  • Biomedical Optics
  • Materials Science

Background:

  • Upconversion nanoparticles (UCNPs) are valuable exogenous contrast agents for bioimaging applications.
  • Swept source optical coherence tomography (SSOCT) offers non-invasive cross-sectional imaging of biological tissues.
  • Enhancing SSOCT contrast at the molecular level remains a key challenge in bioimaging.

Purpose of the Study:

  • To develop polymerically modified UCNPs as enhanced contrast agents for SSOCT.
  • To investigate the effect of different polymer coatings (PEG and PVP) on UCNP performance in SSOCT.
  • To evaluate the in-vivo diffusion dynamics and imaging capabilities of functionalized UCNPs.

Main Methods:

  • Synthesis of functionalized NaYF4: Ho3+/Yb3+ UCNPs with polyethylene glycol (PEG) and polyvinylpyrrolidone (PVP) coatings.
  • In-vivo time-dependent diffusion dynamics studies using a mice model.
  • SSOCT imaging of inactive and excited UCNPs using a custom-built optical system with a 980 nm laser source.

Main Results:

  • Polyvinylpyrrolidone (PVP)-coated UCNPs exhibited improved scattering coefficients and contrast-to-noise ratio in SSOCT imaging compared to polyethylene glycol (PEG)-coated UCNPs.
  • Functionalized UCNPs demonstrated enhanced imaging contrast at the molecular level.
  • The developed system shows potential for theranostic applications, including tumor imaging during photodynamic therapy.

Conclusions:

  • Polymerically modified UCNPs, particularly with PVP coating, represent a promising contrast agent for advancing SSOCT bioimaging.
  • The study highlights the potential for UCNPs to improve tissue contrast and enable molecular-level imaging.
  • The developed system offers a foundation for future theranostic applications in cancer treatment.