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Why chitosan could be apt candidate for glaucoma drug delivery - An overview
B N Kumara1, Rashmi Shambhu2, K Sudhakara Prasad3
1Nanomaterial Research Laboratory [NMRL], Nano Division, Yenepoya Research Centre, Yenepoya [Deemed to be University], Deralakatte, Mangalore 575 018, India.
International Journal of Biological Macromolecules
|February 13, 2021
Summary
Chitosan offers a promising solution for sustained ocular drug delivery in glaucoma management, overcoming limitations of current treatments and enhancing bioavailability for improved patient outcomes.
Area of Science:
- Ophthalmology
- Biomaterials Science
- Drug Delivery Systems
Background:
- Glaucoma affects millions globally, causing irreversible blindness.
- Current ocular drug delivery methods for glaucoma face challenges like poor adhesion, penetration, and burst release.
- Biodegradable and non-biodegradable polymers are explored for enhanced bioavailability, but issues persist.
Purpose of the Study:
- To highlight chitosan as a superior material for ocular drug delivery in glaucoma management.
- To review recent patents utilizing chitosan for ocular drug delivery.
- To identify future perspectives, challenges, and lacunae in chitosan-based ocular delivery systems.
Main Methods:
- Literature review focusing on chitosan's properties for ocular drug delivery.
- Comprehensive review of recent patents on chitosan-based ocular drug delivery platforms.
- Analysis of factors influencing ocular delivery and identification of research gaps.
Main Results:
- Chitosan exhibits excellent physicochemical properties that address existing ocular drug delivery limitations.
- Recent patents demonstrate chitosan's versatility as a platform for sustained ocular drug delivery.
- Key challenges and areas for future research in chitosan-based glaucoma treatments are identified.
Conclusions:
- Chitosan presents a highly effective and promising material for advanced ocular drug delivery in glaucoma.
- Further research and development are needed to optimize chitosan-based systems for efficient and targeted glaucoma management.
- Addressing identified lacunae will pave the way for improved patient outcomes in glaucoma therapy.
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