Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Microorganisms in Medicine and Therapeutics

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.

DNA Bacteriophages

DNA Bacteriophages

Bacteriophages, or phages, are viruses that specifically infect bacteria, utilizing their genetic material to hijack host cellular machinery for replication. DNA bacteriophages employ single-stranded DNA (ssDNA) or double-stranded DNA (dsDNA) genomes. These phages exhibit diverse replication strategies and host interactions, influencing their ecological roles and applications in biotechnology and medicine.ssDNA BacteriophagesssDNA phages, with their small genomes, utilize unique strategies to...

Lytic Cycle of Bacteriophages

Lytic Cycle of Bacteriophages

Bacteriophages, also known as phages, are specialized viruses that infect bacteria. A key characteristic of phages is their distinctive “head-tail” morphology. A phage begins the infection process (i.e., lytic cycle) by attaching to the outside of a bacterial cell. Attachment is accomplished via proteins in the phage tail that bind to specific receptor proteins on the outer surface of the bacterium. The tail injects the phage’s DNA genome into the bacterial cytoplasm. In the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A standardized workflow for typing S. marcescens outbreaks using FT-IR spectroscopy.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2026

Same author

Characterization and host range associating factors of Staphylococcus aureus bacteriophage PBSA08; Using Australian MRSA reference set.

International journal of antimicrobial agents·2026

Same author

Phylogenetic and genome-wide analysis of codon usage reveals geographic and host-specific adaptation in Vaccinia virus.

Archives of virology·2026

Same author

Pyrogenicity of phage active pharmaceutical ingredients used for personalized therapy in Belgium.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V·2026

Same author

Genetic traits of IncK2 plasmids and the <i>Escherichia coli</i> host underlying the association to the chicken gut.

Microbial genomics·2026

Same author

Formulating and stabilising therapeutic phages: A review.

International journal of antimicrobial agents·2026

Same journal

Unlocking the biotechnological potential of traditional fermented food microbiomes.

Current opinion in biotechnology·2026

Same journal

Upcycling food processing byproducts via advanced yeast fermentation.

Current opinion in biotechnology·2026

Same journal

Microbial C1 assimilation pathways for chemical synthesis: from native metabolism to synthetic design.

Current opinion in biotechnology·2026

Same journal

Medicinal plants fermentation: current knowledge and perspectives.

Current opinion in biotechnology·2026

Same journal

Fermented foods: lessons learned from metagenomics.

Current opinion in biotechnology·2026

Same journal

Microfluidic platforms for the transient transfection of mammalian cells: recent developments and challenges.

Current opinion in biotechnology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Nov 17, 2025

Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins

Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins

Published on: June 11, 2015

Phage Biobank: Present Challenges and Future Perspectives.

Ruby Cy Lin¹, Jessica C Sacher², Pieter-Jan Ceyssens³

¹Centre for Infectious Diseases and Microbiology, Westmead Institute for Medical Research, Sydney, Australia; Faculty of Medicine and Health, School of Medical Sciences, The University of Sydney, Sydney, Australia; School of Medical Sciences, University of New South Wales, Sydney, Australia.

Current Opinion in Biotechnology

|February 13, 2021

Summary

This summary is machine-generated.

Developing a national phage biobank is crucial for improving the safety, reproducibility, and speed of therapeutic bacteriophage (phage) delivery for human infections. This initiative aims to streamline phage therapy access and development.

More Related Videos

Understanding the Impact of Temperate Bacteriophages on Their Lysogens Through Transcriptomics

Understanding the Impact of Temperate Bacteriophages on Their Lysogens Through Transcriptomics

Published on: January 5, 2024

Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management

Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management

Published on: November 30, 2022

Related Experiment Videos

Last Updated: Nov 17, 2025

Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins

Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins

Published on: June 11, 2015

Understanding the Impact of Temperate Bacteriophages on Their Lysogens Through Transcriptomics

Understanding the Impact of Temperate Bacteriophages on Their Lysogens Through Transcriptomics

Published on: January 5, 2024

Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management

Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management

Published on: November 30, 2022

Area of Science:

Microbiology
Biotechnology
Public Health

Background:

Therapeutic bacteriophages (phages) have been used for human infections for over a century.
Current phage preparation and administration rely on informal collaborations between researchers, biotech firms, clinicians, and regulators.
There is a significant need to enhance the reproducibility, safety, and speed of providing suitable phages for therapeutic use.

Purpose of the Study:

To discuss the characteristics and challenges of establishing a sustainable phage biobank.
To propose a roadmap for national biobanking and phage therapy initiatives.
To use the Australian context as a model for developing a national consortium for phage therapeutics.

Main Methods:

Reviewing the requirements for a sustainable phage biobank.
Outlining a strategic plan for national biobanking infrastructure.
Identifying key challenges and proposing solutions for phage therapy implementation.

Main Results:

The study identifies critical factors for creating a functional and sustainable phage biobank.
A proposed roadmap addresses the complexities of national-level phage therapy initiatives.
The Australian context serves as a practical model for establishing such programs.

Conclusions:

A national biobanking strategy is essential for advancing phage therapy.
Standardization and collaboration are key to overcoming current limitations in phage preparation and administration.
Implementing a national consortium can accelerate the delivery of safe and effective phage therapeutics.