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Updated: Nov 17, 2025
System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis
Published on: April 5, 2017
Improved method for tuberculocidal and mycobactericidal activity testing of disinfectants based on the European
F H H Brill1, J Lenz2, C Lach2
1Dr. Brill + Partner GmbH Institut für Hygiene und Mikrobiologie, Hamburg, Germany.
Abstract:
Safe measurements to prevent the transmission of (multidrug-resistant) mycobacteria such as disinfection are essential in healthcare settings. In Europe chemical disinfectants are tested for their tuberculocidal and mycobactericidal efficacy by the internationally accepted test procedure described in EN 14348. However, especially for amine-based disinfectants, invalid results may occur by this procedure due to insufficient neutralization. In this multi-laboratory study the procedure described in EN 14348 was optimized by a combination of chemical neutralization and membrane filtration in order to obtain a valid and secure method especially for amine-based disinfectants.
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