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Updated: Nov 17, 2025
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Spontaneous Murine Model of Anaplastic Thyroid Cancer
Published on: February 3, 2023
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Anaplastic Thyroid Carcinoma: Current Issues in Genomics and Therapeutics
Ichiro Abe1,2, Alfred King-Yin Lam3,4,5
1Cancer Molecular Pathology, School of Medicine, Griffith University, Gold Coast Campus, Gold Coast, QLD, 4222, Australia.
Current Oncology Reports
|February 14, 2021
Summary
Anaplastic thyroid carcinoma, an aggressive cancer, shows common mutations like p53 and TERT promoter. Advances in targeted therapies and immunotherapy offer new hope for improved patient management.
Area of Science:
- Oncology
- Genomics
- Molecular Biology
Background:
- Anaplastic thyroid carcinoma (ATC) is the most aggressive form of thyroid cancer.
- Understanding its genomic landscape is crucial for developing effective treatments.
Purpose of the Study:
- To review current genomic alterations in ATC.
- To discuss the impact of recent therapeutic advances on patient management.
Main Methods:
- Review of genomic studies identifying common mutations in ATC.
- Analysis of ongoing clinical trials for novel targeted therapies and immunotherapies.
Main Results:
- Frequent mutations include p53, TERT promoter, BRAF, RAS, and others.
- MicroRNA expression changes are implicated in ATC pathogenesis.
- Established treatments include surgery, radiotherapy, and chemotherapy; novel therapies target cell membrane kinases and downstream pathways.
Conclusions:
- Updated knowledge of ATC genomics and clinical trials is essential.
- Improving patient management requires integrating genomic insights with novel therapeutic strategies.
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