Heart Matters: Cardiac Dysfunction and Other Autonomic Changes in Parkinson's Disease
Valeria C Gonçalves1,2,3, Lorena Cuenca-Bermejo1,2, Emiliano Fernandez-Villalba1,2
1Clinical & Experimental Neuroscience (NiCE), Biomedical Research Institute of Murcia (IMIB- Arrixaca), Murcia, Spain.
Summary
Parkinson's disease (PD) involves non-motor symptoms like autonomic dysfunction, which can precede motor symptoms and aid early diagnosis. Cardiovascular monitoring may offer prodromal insights into PD progression and related heart conditions.
Area of Science:
- Neurology
- Cardiology
- Medical Research
Background:
- Parkinson's disease (PD) is a progressive neurodegenerative disorder with over 200 years of research.
- Current treatments manage symptoms but cannot prevent PD progression, as neurodegeneration begins before motor diagnosis.
- Non-motor symptoms, particularly autonomic dysfunctions, are prevalent in PD and can indicate early disease stages.
Approach:
- This review synthesizes existing literature on Parkinson's disease.
- Focuses on the relationship between PD and cardiovascular parameters.
- Highlights the role of autonomic dysfunction as a non-motor manifestation.
Key Points:
- Autonomic dysfunctions affect a majority of Parkinson's disease patients.
- Cardiovascular diseases are frequently correlated with Parkinson's disease.
- Heart failure is a leading cause of mortality in Parkinson's disease patients.
Conclusions:
- Early diagnosis of Parkinson's disease may be facilitated by recognizing non-motor symptoms like autonomic dysfunction.
- Cardiovascular monitoring and dysfunction identification could serve as prodromal indicators for Parkinson's disease.
- Understanding the relationship between cardiovascular health and Parkinson's disease is crucial for patient management.
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