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Updated: Nov 17, 2025

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases
Published on: June 14, 2021
MANAGEMENT OF LARGE OR RECURRENT MACULAR HOLES
Hailey Kay Robles-Holmes1, Patrick C Staropoli1, Nicolas Yannuzzi1
1Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL.
Purpose Of Review:
To review and critically appraise the recent literature about new surgical techniques for the management of large or recurrent macular holes.
Recent Findings:
A variety of surgical approaches have recently been developed ranging from autologous retinal grafts to amniotic membrane transplant with varying levels of anatomical and visual success.
Summary:
More data is needed to determine if one technique is superior to others. However, with a variety of grafts, adhesives, and tamponades at their disposal, vitreoretinal surgeons have an extensive array of options to approach complex macular holes.
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