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Acute oral treatment with resveratrol and Lactococcus Lactis Subsp. Lactis decrease body weight and improve liver
Keila Lopes Mendes1,2, Deborah de Farias Lelis1, Daniela Fernanda de Freitas1
1Laboratory of Health Science, Postgraduate Program in Health Science, Department of Health Science, Hospital Universitário Clemente Faria, Universidade Estadual de Montes Claros (Unimontes), Avenida Cula Mangabeira, 562 - Santo Expedito, Montes Claros, Minas Gerais, CEP 39401-001, Brazil.
This study found that combining resveratrol and Lactococcus lactis improved metabolic health and reduced inflammation markers in mice. This combination shows promise for managing metabolic disorders and liver inflammation.
Area of Science:
- Nutritional Science
- Microbiology
- Immunology
Background:
- Metabolic disorders and liver inflammation are significant health concerns.
- Nutraceuticals like resveratrol and probiotics such as Lactococcus lactis are explored for therapeutic benefits.
Purpose of the Study:
- To investigate the combined effects of resveratrol and Lactococcus lactis on metabolic parameters.
- To assess the impact on hepatic proinflammatory markers expression.
Main Methods:
- C57BL/6 mice were grouped into Standard, Lactococcus lactis (LL), Resveratrol (RSV), and LL + RSV.
- Administration was via orogastric gavage.
- Evaluated blood parameters (cholesterol, triglycerides, ALT, AST), IL-6 mRNA, and TNF-α protein.
Main Results:
- The combination of resveratrol and Lactococcus lactis reduced body weight, AST, and total cholesterol.
- Both LL and LL + RSV groups showed decreased triglycerides, IL-6, and TNF-α expression.
- Resveratrol and Lactococcus lactis demonstrated synergistic effects on metabolic and inflammatory markers.
Conclusions:
- Resveratrol and Lactococcus lactis can improve metabolic parameters and reduce hepatic inflammation.
- This combination presents a potential strategy for preventing metabolic diseases and liver inflammation.
