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Noncoding RNAs in osteosarcoma: Implications for drug resistance

Zhengjun Lin1, Xubin Xie2, Shiyao Lu2

  • 1Department of Orthopedics, The Second Xiangya Hospital of Central South University, 139 Renmin Road, Changsha, 410011, Hunan, People's Republic of China; Xiangya School of Medicine, Central South University, Changsha, 410013, Hunan Province, China.

Cancer Letters
|February 15, 2021
PubMed

Insights

Noncoding RNAs (ncRNAs) are key players in osteosarcoma drug resistance, hindering treatment effectiveness. Targeting these ncRNAs offers a promising strategy to overcome multi-drug resistance (MDR) and improve patient outcomes.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Osteosarcoma is the most common bone cancer in children and adolescents.
  • Current treatments for osteosarcoma have plateaued in improving survival rates.
  • Multi-drug resistance (MDR) is a major challenge in osteosarcoma chemotherapy.

Purpose of the Study:

  • To review the roles of noncoding RNAs (ncRNAs) in osteosarcoma chemoresistance.
  • To elucidate the molecular mechanisms by which ncRNAs regulate drug resistance.
  • To discuss ncRNAs as potential biomarkers and therapeutic targets for osteosarcoma.

Main Methods:

  • Systematic review of existing literature on ncRNAs and osteosarcoma drug resistance.
  • Analysis of molecular mechanisms underlying ncRNA-mediated chemoresistance.
  • Discussion of therapeutic implications and biomarker potential of ncRNAs.

Main Results:

  • Noncoding RNAs (ncRNAs), including miRNAs, lncRNAs, and circRNAs, are frequently dysregulated in osteosarcoma.
  • These ncRNAs significantly influence osteosarcoma cell sensitivity to chemotherapy drugs.
  • Various molecular pathways are modulated by ncRNAs to induce or overcome drug resistance.

Conclusions:

  • Noncoding RNAs play critical roles in the development and progression of osteosarcoma chemoresistance.
  • Targeting specific ncRNAs presents a novel therapeutic avenue to overcome MDR in osteosarcoma.
  • ncRNAs hold promise as diagnostic and prognostic biomarkers for osteosarcoma patients.
Keywords:
Circular RNADrug resistanceLong noncoding RNAMicroRNAOsteosarcoma

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