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Related Concept Videos

Olefin Metathesis Polymerization: Acyclic Diene Metathesis (ADMET)00:53

Olefin Metathesis Polymerization: Acyclic Diene Metathesis (ADMET)

Acyclic diene metathesis polymerization or ADMET polymerization involves cross-metathesis of terminal dienes, such as 1,8-nonadiene, to give linear unsaturated polymer and ethylene. As ADMET is a reversible process, the formed ethylene gas must be removed from the reaction mixture to complete the polymerization process.
Similar to cross-metathesis, ADMET also involves the formation of metallacyclobutane intermediate by [2+2] cycloaddition of one of the double bonds of a terminal diene with...

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Updated: Jun 30, 2026

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Cyclo olefin polymer-based solvent-free mass-productive microphysiological systems.

Makoto Yamanaka1, Xiaopeng Wen2, Satoshi Imamura2

  • 1Incubation Center Organs On Chip Project, Ushio INC, 1-6-5 Marunouchi, Chiyoda-ku, Tokyo 100-8150, Japan.

Biomedical Materials (Bristol, England)
|February 15, 2021
PubMed
Summary

A new cyclo olefin polymer (COP)-based microphysiological system (MPS) overcomes limitations of polydimethylsiloxane (PDMS) materials. This COP-VUV-MPS offers improved drug screening and toxicological testing by preventing molecule absorption and maintaining cell stemness.

Keywords:
cyclo olefin polymerhuman pluripotent stem cellsmicrophysiological systempolydimethylsiloxanevacuum ultraviolet

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Area of Science:

  • Biomaterials Science
  • Cell Biology
  • Toxicology

Background:

  • Microphysiological systems (MPS) are promising alternatives to animal models for drug screening and toxicology.
  • Polydimethylsiloxane (PDMS)-based MPS face challenges including drug absorption, material-induced cellular effects, and mass production difficulties.

Purpose of the Study:

  • To develop a novel cyclo olefin polymer (COP)-based MPS (COP-VUV-MPS) to address the limitations of PDMS-based systems.
  • To evaluate the performance of COP-VUV-MPS for drug screening and toxicological applications.

Main Methods:

  • Fabrication of MPS using COP with metal molding and vacuum ultraviolet (VUV) photobonding.
  • Comparison of COP-VUV-MPS with PDMS-based MPS (PDMS-MPS).
  • Assessment of chemical resistance, molecule absorption, and effects on human-induced pluripotent stem cells (hiPSCs).

Main Results:

  • COP-VUV-MPS demonstrated superior chemical resistance and prevented molecule absorption compared to PDMS-MPS.
  • The COP-VUV-MPS maintained the stemness of hiPSCs without inducing adverse cellular phenotypes or gene expression changes.
  • Metal molding enabled rapid mass production of COP-VUV-MPS with high fidelity microstructures.

Conclusions:

  • COP-VUV-MPS offers a viable alternative to PDMS-based systems for drug development and in vitro toxicological testing.
  • The material stability and fabrication process of COP-VUV-MPS enhance its applicability for advanced biological assays.
  • This novel MPS platform shows potential for accurate and reliable cell-based testing.