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Inverse association between systemic immune-inflammation index and bone mineral density in postmenopausal women
Systemic immune-inflammation index (SII) is linked to lower bone mineral density (BMD) in postmenopausal women. This inflammatory marker may predict bone loss, independent of other risk factors.
Area of Science:
- Endocrinology
- Immunology
- Osteoporosis Research
Background:
- Postmenopausal osteoporosis is a significant health concern.
- Biomarkers reflecting inflammation may influence bone health.
Purpose of the Study:
- To examine the association between systemic immune-inflammation index (SII) and neutrophil-to-platelet ratio (NLR) with bone mineral density (BMD) in postmenopausal women.
Main Methods:
- Cross-sectional study of 413 postmenopausal women without hormone therapy.
- Linear regression analysis was used to assess the relationship between SII, NLR, and BMD.
Main Results:
- A significant inverse association was found between SII and BMD.
- Lower BMD was observed with increasing quartiles of SII.
- NLR showed an inverse association with BMD, but it was not significant after adjusting for covariates.
Conclusions:
- SII is negatively associated with BMD in postmenopausal women, independent of major risk factors.
- SII emerges as a potential novel predictor for bone loss in this population.
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