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Investigation of Plant Interactions Across Common Mycorrhizal Networks Using Rotated Cores
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Chemical Exchanges between Multilateral Symbionts.

Munhyung Bae1, Emily Mevers1, Gleb Pishchany1

  • 1Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United States.

Organic Letters
|February 16, 2021
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Summary
This summary is machine-generated.

Researchers discovered two new metabolites, conocandin B and dentigerumycin F, from a fungal-bacterial symbiosis. Conocandin B shows antimicrobial properties by inhibiting fatty acid biosynthesis.

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Area of Science:

  • Microbiology
  • Natural Product Chemistry
  • Chemical Ecology

Background:

  • Multilateral symbiotic relationships involve complex molecular exchanges.
  • Fungal and bacterial symbionts engage in reciprocal interactions.
  • Understanding these exchanges can reveal novel bioactive compounds.

Purpose of the Study:

  • To investigate the molecular interactions within a multilateral symbiosis.
  • To identify and characterize novel metabolites produced by symbiotic partners.
  • To evaluate the biological activity of the discovered compounds.

Main Methods:

  • Nuclear Magnetic Resonance (NMR) spectroscopy for structural elucidation.
  • Mass spectrometry for molecular weight determination.
  • Genomic analysis and chemical derivatizations to confirm structures.

Main Results:

  • Characterization of two new metabolites: conocandin B (fungal) and dentigerumycin F (bacterial).
  • Conocandin B demonstrated significant antimicrobial activity against bacterial symbionts and human pathogens.
  • The mechanism of action for conocandin B involves selective inhibition of FabH, disrupting fatty acid biosynthesis.

Conclusions:

  • The study elucidated a molecular exchange in a multilateral symbiosis, yielding new metabolites.
  • Conocandin B represents a promising antimicrobial agent with a defined mechanism of action.
  • This work highlights the potential of symbiotic interactions for natural product discovery.