Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Oogenesis02:07

Oogenesis

67.5K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
67.5K
Oogenesis01:22

Oogenesis

3.0K
Oogenesis,  the process of developing egg cells (female gametes), occurs within the ovaries and is fundamental to female fertility. This sequence begins during fetal development when diploid oogonia in the developing ovaries undergo mitotic divisions to produce primary oocytes. By birth, these primary oocytes enter prophase I of meiosis but become arrested in this stage, remaining suspended until puberty.
Each primary oocyte is surrounded by a layer of pre-granulosa cells, forming what is...
3.0K
Meiosis vs. Mitosis02:57

Meiosis vs. Mitosis

64.6K
Cell division is necessary for growth and reproduction in organisms. Mitosis aids cell growth and development by dividing somatic cells. In contrast, meiosis causes the division of germ cells and plays an essential role in sexual reproduction. Due to their unique functional requirements, mitosis and meiosis differ from each other in multiple aspects.
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...
64.6K
Nondisjunction01:21

Nondisjunction

4.4K
Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers.  Nondisjunction is common during anaphase I or anaphase II of meiosis.  Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold...
4.4K
Meiosis I03:09

Meiosis I

43.2K
Meiosis is the division of a diploid cell into haploid cells forming sperm and eggs in animals through differentiation. Meiosis I is the first stage of meiosis, where the genetic recombination of homologous chromosomes and the reduction of the ploidy level by half occurs.
Prophase I is the most extended and complex step of meiosis I characterized by synapsis, chromosome pairing, and recombination of the homologous chromosomes. This process is facilitated by a proteinaceous structure called the...
43.2K
Teratogenicity01:07

Teratogenicity

3.7K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
3.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Beyond the Scale: Effects of Maternal Obesity on Embryo Morphokinetics and IVF Outcomes.

Journal of clinical medicine·2026
Same author

Alterations in Implantation Genes and Dendritic Cells in Endometrial Samples After Antibiotic Treatment.

Journal of clinical medicine·2025
Same author

Non-Male Factor Only-ICSI Can Overcome Oocyte Factor in PCOS Patients.

Journal of clinical medicine·2025
Same author

Mid-infrared spectroscopy as a real-time diagnostic tool for chronic endometritis: A preliminary study.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy·2025
Same author

Does Endometrial Thickness or Compaction Impact the Success of Frozen Embryo Transfer? A Cohort Study Analysis.

Journal of clinical medicine·2024
Same author

Excess Weight Impairs Oocyte Quality, as Reflected by mtDNA and BMP-15.

Cells·2024

Related Experiment Video

Updated: Nov 17, 2025

Human Egg Maturity Assessment and Its Clinical Application
08:51

Human Egg Maturity Assessment and Its Clinical Application

Published on: August 19, 2019

19.8K

Embryonic Development in Relation to Maternal Age and Conception Probability.

Oshrit Lebovitz1,2,3,4, Mediea Michaeli5, Nardin Aslih5,6

  • 1IVF and Infertility Unit, Hillel Yaffe Medical Center, Hadera, Israel. lebovitzo@gmail.com.

Reproductive Sciences (Thousand Oaks, Calif.)
|February 16, 2021
PubMed
Summary
This summary is machine-generated.

Maternal age impacts early embryo development. Advanced maternal age (AMA) is linked to slower embryo development, and faster-developing embryos increase conception chances, especially for AMA women.

Keywords:
Advanced maternal ageEmbryo developmentIntracytoplasmic sperm injection cyclesMorphokinetic parametersTime-lapse imaging

More Related Videos

Using Mouse Oocytes to Assess Human Gene Function During Meiosis I
11:13

Using Mouse Oocytes to Assess Human Gene Function During Meiosis I

Published on: April 10, 2018

9.2K
Analysis of Chromosome Segregation, Histone Acetylation, and Spindle Morphology in Horse Oocytes
12:11

Analysis of Chromosome Segregation, Histone Acetylation, and Spindle Morphology in Horse Oocytes

Published on: May 11, 2017

11.2K

Related Experiment Videos

Last Updated: Nov 17, 2025

Human Egg Maturity Assessment and Its Clinical Application
08:51

Human Egg Maturity Assessment and Its Clinical Application

Published on: August 19, 2019

19.8K
Using Mouse Oocytes to Assess Human Gene Function During Meiosis I
11:13

Using Mouse Oocytes to Assess Human Gene Function During Meiosis I

Published on: April 10, 2018

9.2K
Analysis of Chromosome Segregation, Histone Acetylation, and Spindle Morphology in Horse Oocytes
12:11

Analysis of Chromosome Segregation, Histone Acetylation, and Spindle Morphology in Horse Oocytes

Published on: May 11, 2017

11.2K

Area of Science:

  • Reproductive Science
  • Embryology
  • Infertility Research

Background:

  • Limited data exists on the association between maternal age and early embryo development.
  • Understanding these differences is crucial for optimizing fertility treatments.

Purpose of the Study:

  • To compare early embryo development kinetics between young and advanced maternal age (AMA) women.
  • To assess if embryo development speed differs between embryos that lead to pregnancy versus those that do not.

Main Methods:

  • Retrospective analysis of 2021 oocytes from 364 intracytoplasmic sperm injection (ICSI) cycles using time-lapse imaging.
  • Evaluation of kinetic markers including time to pronuclei fading (tPNf) and cell cleavage (t2-t8).
  • Assessment of blastocyst development times (tM, tSB, tB, tEB).

Main Results:

  • Embryos from younger women showed significantly faster development times (t3, t4, t5, t6, tSB, tB, tEB) compared to AMA women (p < 0.05).
  • Embryos resulting in pregnancy exhibited faster development (shorter t2 and t8) in both age groups compared to non-pregnant outcomes (p < 0.05).

Conclusions:

  • Advanced maternal age is associated with delayed embryonic development.
  • Faster early embryonic development is a predictor of successful pregnancy.
  • Selecting faster-developing embryos for transfer may enhance conception rates in women of AMA.