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A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions
Published on: July 18, 2013
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Viral Host Range database, an online tool for recording, analyzing and disseminating virus-host interactions
Quentin Lamy-Besnier1,2, Bryan Brancotte3, Hervé Ménager3
1Bacteriophage, Bacterium, Host Laboratory, Department of Microbiology, Institut Pasteur, Paris F-75015, France.
Bioinformatics (Oxford, England)
|February 17, 2021
Summary
A new Viral Host Range database (ViralHostRangeDB) was created to centralize experimental data on virus-host interactions across archaea, bacteria, and eukaryotes, addressing a critical information gap.
Area of Science:
- Virology
- Bioinformatics
- Microbiology
Background:
- Viruses infect diverse hosts, a characteristic known as host range.
- Comprehensive data on virus-host specificity is currently lacking and fragmented.
- Understanding virus host range is crucial for various biological and medical applications.
Purpose of the Study:
- To develop a centralized, accessible resource for experimental virus host range data.
- To facilitate the analysis and dissemination of information on which viruses infect which hosts.
- To support research in virology, microbial ecology, and host-pathogen interactions.
Main Methods:
- Development of a web-based application, ViralHostRangeDB.
- Systematic curation and integration of experimental host range data for viruses.
- Data categorization for viruses infecting archaea, bacteria, and eukaryotes.
Main Results:
- The Viral Host Range database (ViralHostRangeDB) is now available online.
- The database provides a comprehensive record of experimentally verified virus-host interactions.
- Facilitates querying and analysis of virus infectivity across different domains of life.
Conclusions:
- ViralHostRangeDB serves as a valuable resource for researchers studying virus-host relationships.
- The database aids in understanding viral diversity and host specificity.
- Promotes further research and potential applications in disease control and biotechnology.
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