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Phenolic-enabled nanotechnology: versatile particle engineering for biomedicine
Di Wu1, Jiajing Zhou, Matthew N Creyer
1College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China. chenzhong@zju.edu.cn.
Chemical Society Reviews
|February 17, 2021
Summary
Phenolic-enabled nanotechnology (PEN) offers versatile, biocompatible materials for advanced biomedical uses. This review details PEN synthesis strategies and applications in biosensing, bioimaging, and disease treatment.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Phenolics are natural compounds with unique properties driving research.
- Phenolic-enabled nanotechnology (PEN) leverages these properties for biomedical applications, notably polydopamine and polyphenols.
Purpose of the Study:
- To provide a comprehensive overview of PEN mechanisms and synthetic strategies.
- To summarize PEN applications in state-of-the-art biomedical fields.
- To offer guidelines for researchers and insights into translational PEN research.
Main Methods:
- Review of fundamental mechanisms and synthetic strategies in PEN.
- Analysis of particle engineering and bottom-up synthesis of nanohybrid materials.
- Discussion of intermolecular forces for controlled synthesis of phenolic nanomaterials.
Main Results:
- Detailed exploration of PEN principles and synthetic toolkit.
- Synthesis of high-quality phenolic nanomaterials with controllable characteristics.
- Highlighting applications in biosensing, bioimaging, and disease treatment.
Conclusions:
- PEN is a rapidly advancing field with significant potential in biomedicine.
- Controllable synthesis via understanding phenolic interactions is key.
- PEN shows promise for translational research in diagnostics and therapeutics.
