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Updated: Nov 17, 2025

A Rapid Method for Multispectral Fluorescence Imaging of Frozen Tissue Sections
Published on: March 30, 2020
Selective sensing of DNA and live/dead cells and histological imaging based on a perylene derivative
Jun-Fang Wang1, Chun-Miao Zhao1, Jian-Xing Yang1
1College of Chemistry and Environmental Science, Hebei University, Baoding, 071002, P. R. China. kerangwang@hbu.edu.cn and Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Key Laboratory of Chemical Biology of Hebei Province, Hebei University, Baoding, 071002, P. R. China.
Abstract:
A mannose-modified perylene monoimide derivative PMI-Man was developed, which shows highly selective binding to double-stranded DNA molecules, potent live/dead cell imaging, and histological imaging via both confocal and light microscopies. This approach can be used to develop a universal colorful staining method for human tissues for both confocal and light microscopies.
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