Related Experiment Video
Updated: Nov 17, 2025
04:36
Measurement of Tissue Oxygenation Using Near-Infrared Spectroscopy in Patients Undergoing Hemodialysis
Published on: October 2, 2020
2.4K
Expanded Hemodialysis and Its Effects on Hospitalizations and Medication Usage: A Cohort Study
Rafael M Sanabria1, Colin A Hutchison2, Jasmin I Vesga3
1Renal Therapy Services-Latin America, Bogotá, Colombia, mauricio_sanabria@baxter.com.
Nephron
|February 17, 2021
Summary
Switching to expanded hemodialysis (HDx) reduced hospitalizations and medication needs for end-stage kidney disease (ESKD) patients. This innovative hemodialysis therapy shows promise in easing patient and healthcare burdens.
Area of Science:
- Nephrology
- Renal Replacement Therapy
- Uremic Toxin Management
Background:
- End-stage kidney disease (ESKD) management often involves hemodialysis (HD).
- High-flux HD removes uremic toxins but may also remove beneficial proteins like albumin.
- Expanded hemodialysis (HDx) targets larger uremic toxins while preserving albumin.
Purpose of the Study:
- To evaluate the impact of switching from high-flux HD to HDx.
- To compare clinical laboratory parameters, hospitalization rates, and medication use.
- To assess the potential benefits of HDx in ESKD patients.
Main Methods:
- Multicenter, observational cohort study.
- 81 adult ESKD patients on chronic HD were switched to HDx.
- Follow-up was conducted for 1 year post-switch.
Main Results:
- Hospital day rate per patient-year significantly decreased (p = 0.0001).
- Mean doses of erythropoiesis-stimulating agents and intravenous iron significantly decreased (p = 0.0361 and p = 0.0003).
- Hospitalization event rate showed a non-significant decrease.
Conclusions:
- Switching to HDx is associated with reduced hospital days and medication requirements.
- HDx demonstrates potential to lessen the burden of ESKD on patients and healthcare systems.
- Further research may explore long-term outcomes and cost-effectiveness.
Related Concept Videos
01:24Hemodialysis II: Procedure and Complications
302
DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
302
01:25Hemodialysis III: Nursing Management
428
The nursing management of a patient undergoing hemodialysis includes several critical steps, starting with a thorough assessment before the procedure.Before the Hemodialysis ProcedureFirst, record the patient's vital signs—blood pressure, heart rate, respiratory rate, and temperature—to establish a baseline. This baseline is essential for detecting conditions such as hypotension that could impact the patient's response to dialysis. Document the patient's pre-dialysis weight, as this...
428
01:25Hemodialysis I: Introduction
682
Hemodialysis (HD) is a medical treatment that artificially removes waste products, excess fluids, and toxins from the blood when the kidneys are no longer able to perform these functions effectively. In this process, blood is filtered through a semipermeable membrane, allowing for the selective removal of waste while preserving necessary components like blood cells and proteins. Hemodialysis is typically performed in patients with end-stage renal disease (ESRD) or severe kidney...
682
01:30Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis
101
Patients with end-stage renal disease (ESRD) or those experiencing drug overdose often require extracorporeal methods to eliminate accumulated drugs and metabolites. Hemoperfusion, hemofiltration, and dialysis are the primary techniques to rapidly remove harmful substances without disrupting the patient's fluid and electrolyte balance. For those with compromised renal function, dosage adjustments of concurrent medications may be necessary during extracorporeal drug removal.Dialysis is a process...
101
01:25Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications
220
Peritoneal dialysis (PD) is a medical process that removes waste products and excess fluid from the body using the peritoneal membrane as a natural filter.Peritoneal Dialysis MethodsSeveral methods can be used for peritoneal dialysis, including Acute Intermittent Peritoneal Dialysis, Continuous Ambulatory Peritoneal Dialysis, and Automated Peritoneal Dialysis, also known as Continuous Cyclic Peritoneal Dialysis.Acute Intermittent Peritoneal Dialysis (AIPD) is used for patients with uremic...
220
01:25Peritoneal Dialysis III: Nursing Management
326
Peritoneal dialysis, or PD, utilizes the peritoneal membrane as a filter to eliminate excess fluid and waste products. Effective nursing management is essential for ensuring patient safety, preventing complications, and promoting optimal function of the peritoneal dialysis process.Assessment and MonitoringNurses must thoroughly assess the patient before, during, and after each dialysis session. Regular monitoring includes vital signs, daily weight, fluid intake and output, and laboratory values...
326