Related Experiment Video
Updated: Nov 17, 2025
08:50
A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
Published on: June 24, 2020
4.0K
Chorioamnionitis and adverse outcomes in low-risk pregnancies: a population-based study
Diana A Racusin1, Han-Yang Chen1, Asha Bhalwal1
1Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA.
Summary
Chorioamnionitis significantly increases risks for adverse neonatal and maternal outcomes in low-risk pregnancies. This infection also elevates the likelihood of infant mortality, highlighting its serious implications.
Area of Science:
- Obstetrics and Gynecology
- Neonatal Health
- Infectious Diseases in Pregnancy
Background:
- Chorioamnionitis, an infection of the amniotic sac, is a known complication in pregnancy.
- Understanding its impact on low-risk pregnancies is crucial for maternal and infant well-being.
Purpose of the Study:
- To compare composite neonatal and maternal adverse outcomes in low-risk pregnancies with and without chorioamnionitis.
Main Methods:
- Retrospective cohort study using U.S. Vital Statistics Data.
- Inclusion criteria: full-term, low-risk, singleton pregnancies.
- Analysis via multivariable Poisson regression to assess chorioamnionitis association with adverse outcomes.
Main Results:
- 1.7% of 19.7 million live births (meeting criteria) had chorioamnionitis.
- Increased risk of composite neonatal adverse outcome (aRR=3.40; 95% CI=3.30-3.49).
- Increased risk of composite maternal adverse outcome (aRR=2.42; 95% CI=2.31-2.55) and infant mortality (aRR=1.23; 95% CI=1.09-1.38).
Conclusions:
- Chorioamnionitis is linked to significantly higher risks of adverse neonatal and maternal outcomes in low-risk pregnancies.
- The study confirms an increased risk of infant mortality associated with chorioamnionitis.
Related Concept Videos
01:28Acute Pyelonephritis II: Diagnostic Studies and Management
129
Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
129
01:26Factors Affecting the Risk of Infection
13.0K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.0K
01:07Teratogenicity
3.7K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
3.7K
01:27Acute Pyelonephritis I: Introduction
208
Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such...
208
02:07Oogenesis
67.5K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
67.5K