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Related Concept Videos

Treatment Resistant Cancers02:56

Treatment Resistant Cancers

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Primary Lymphoid Organs01:16

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Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
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Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Development of the Lymphatic System01:15

Development of the Lymphatic System

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The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
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Related Experiment Video

Updated: Nov 17, 2025

Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma
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Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma

Published on: September 12, 2025

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Addressing the Challenges of Aggressive Lymphomas.

Katherine L Byar1, Matthew Lunning1

  • 1Fred & Pamela Buffett Cancer Center, Omaha, Nebraska.

Journal of the Advanced Practitioner in Oncology
|February 18, 2021
PubMed
Summary

This presentation discusses managing aggressive lymphomas by using new data and optimal therapies. It also covers strategies for handling treatment side effects in patients with these challenging cancers.

Area of Science:

  • Hematology
  • Oncology
  • Clinical Pharmacy

Background:

  • Aggressive lymphomas present complex treatment challenges.
  • Optimal management requires integrating emerging research and clinical data.

Purpose of the Study:

  • To provide strategies for overcoming challenges in aggressive lymphoma treatment.
  • To review current and emerging therapeutic approaches.
  • To discuss the management of adverse events associated with lymphoma therapies.

Main Methods:

  • Expert review of current literature and clinical trial data.
  • Discussion of treatment recommendations and emerging therapies.
  • Focus on practical application for clinicians managing lymphoma patients.

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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
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A Syngeneic Mouse B-Cell Lymphoma Model for Pre-Clinical Evaluation of CD19 CAR T Cells
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Main Results:

  • Key insights into applying new data for aggressive lymphoma treatment were presented.
  • Optimal therapeutic strategies and recommendations were reviewed.
  • Methods for managing adverse events were discussed.

Conclusions:

  • Effective management of aggressive lymphomas hinges on integrating emerging data and optimizing treatment plans.
  • Proactive management of adverse events is crucial for patient outcomes.
  • Continuous learning and adaptation to new evidence are essential in lymphoma care.