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Expectant Management of Severe COVID-19 Pneumonia in Late Preterm Pregnancy and Subsequent Cholecystitis: Lessons
Neggin B Mokhtari1, Daphnie Drassinower2, Lindsey A Orr3
1Department of Obstetrics and Gynecology, MedStar Washington Hospital Center/Georgetown University, Washington, District of Columbia.
Insights
Delaying delivery is a viable option for pregnant women with severe coronavirus disease 2019 (COVID-19), even in late gestation. A multidisciplinary approach ensures optimal outcomes for both mother and fetus during COVID-19 infection management.
Area of Science:
- Obstetrics and Gynecology
- Infectious Diseases
- Critical Care Medicine
Background:
- Pregnant women with COVID-19 face increased risks of hospitalization and severe outcomes.
- Optimal delivery timing for pregnant patients with COVID-19, particularly in late preterm and early term gestation, remains unclear.
- COVID-19 infection alone is not considered a sole indication for delivery in pregnant individuals.
Observation:
- A case report details a pregnant patient in late third-trimester gestation with severe COVID-19.
- The patient was managed expectantly, showing respiratory improvement without requiring delivery.
- Cholecystitis developed during hospitalization, potentially representing a novel clinical association with COVID-19.
Findings:
- Expectant management and delaying delivery can be a safe option for maternal stabilization in severe COVID-19 cases, even in advanced gestation.
- A multidisciplinary team approach is crucial for managing pregnant women with COVID-19 to achieve optimal maternal and fetal outcomes.
- COVID-19 infection may be associated with other clinical sequelae, such as cholecystitis.
Implications:
- This case suggests that delaying delivery is a reasonable strategy for maternal stabilization in severe COVID-19 during late pregnancy.
- Highlights the necessity of a collaborative, team-based approach in managing pregnant patients with COVID-19.
- Suggests a potential link between COVID-19 infection and the development of cholecystitis in pregnancy.
Abstract:
Introduction Since the emergence of coronavirus disease 2019 (COVID-19) as a pandemic in March 2020, research and guidance have been published with regard to the management of infection and considerations in pregnancy, but much is still unknown. Pregnant women with COVID-19 infection are more likely to be hospitalized and are at increased risk for intensive care unit admissions and intubation than nonpregnant women with COVID-19 infection. The optimal timing of delivery among pregnant women with COVID-19 infection has not been established at this time, especially when the infection arises in late preterm and early term gestation. It is suggested that COVID-19 infection should not be considered a sole indication for delivery. The risks and benefits of prolonging pregnancy versus delivery should be taken into consideration at any given gestational age in a patient with COVID-19 infection. Case Report We report a case of a patient in the late third trimester of pregnancy that presented with severe COVID-19 infection and was managed expectantly through her disease course with improvement of respiratory status without necessitating delivery. We also discuss the unique development of cholecystitis in her hospitalization that may represent another clinical association to COVID-19 infection. Conclusion This case illustrates that delaying delivery is an option even in later gestational ages for maternal stabilization. A multidisciplinary approach and teamwork is needed to manage pregnant women with COVID-19 infection for optimal outcomes for both mother and fetus. Key Points Delaying delivery in severe coronavirus disease 2019 (COVID-19) infection is a reasonable option even in late gestation.A multidisciplinary team is of utmost importance when managing a pregnant woman with COVID-19.Other clinical sequalae such as cholecystitis may arise in the setting of COVID-19 infection.
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