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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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[Kidney involvement in Waldenström's disease - case report].

Luigi Fomasi1, Paolo Foini2, Gianluca Marchi2

  • 1UO Nefrologia e Dialisi ASST Spedali civili di Brescia - Scuola di specializzazione in Nefrologia di Brescia, Italia.

Giornale Italiano Di Nefrologia : Organo Ufficiale Della Societa Italiana Di Nefrologia
|February 18, 2021
PubMed
Summary

Waldenström's disease, a rare B lymphocyte cancer, can cause severe kidney failure. This case study shows successful treatment of nephrotic syndrome in Waldenström's using combination chemotherapy, achieving full remission.

Keywords:
Waldenström’s diseasecyclophosphamidedexamethasonenephrotic syndromerituximab

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Area of Science:

  • Hematology
  • Nephrology
  • Oncology

Background:

  • Waldenström's disease is a rare B-cell neoplasm characterized by lymphoplasmacytic lymphoma and M protein.
  • Renal involvement, though rare, can manifest as severe kidney failure in Waldenström's disease.

Observation:

  • A patient presented with overt nephrotic syndrome secondary to Waldenström's disease.

Findings:

  • The patient received combination chemotherapy including rituximab, cyclophosphamide, and dexamethasone.
  • Treatment resulted in complete hematological and renal remission.

Implications:

  • This case highlights the potential for significant renal complications in Waldenström's disease.
  • Combination chemotherapy offers a viable treatment strategy for managing nephrotic syndrome in this rare hematological malignancy.