Related Experiment Video
Updated: Nov 17, 2025
E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy
Published on: August 1, 2019
The efficacy of on-demand sedation colonoscopy: a STROBE-compliant retrospective cohort study
Hung Leng Kaan1,2,3, Vincent Khor4,5, Wei Chee Liew4,5
1Department of General Surgery, Ng Teng Fong General Hospital, National University Health Systems, Singapore, Singapore. hung_leng_kaan@nuhs.edu.sg.
Background:
Colonoscopy has been routinely performed with sedation. Previous studies showed that on-demand sedation colonoscopy is acceptable in patients. We aim to compare the clinical outcomes of patients undergoing colonoscopy with and without sedation.
Methods:
A prospectively collected retrospective matched cohort study was performed. 290 consecutive patients who underwent colonoscopy without sedation were included into the study. Another 290 patients who underwent colonoscopy with sedation were then selected based on matched sex and age group distribution. Data were collected in a prospective database. Age, sex, race, and procedural variables were collected. Outcomes analyzed included adenoma detection rate, Boston bowel preparation scores, time spent in the recovery room, cecal intubation time, and presence of pain during colonoscopy.
Results:
A total of 580 patients were included in the study. Of the 290 patients who underwent colonoscopy without sedation, 10 patients (3.45%) required sedation to be administered to complete the scope. Intention-to-treat analysis was performed. Multivariate analysis demonstrated that the administration of sedation was a significant predictor of prolonged recovery time (increase in 34.76 min, 95% CI 29.56-39.55, p < 0.001). Comparing the group who underwent colonoscopy without sedation to the group who underwent colonoscopy with sedation, there was no statistically significant difference in mean cecal intubation time (11.28 vs. 10.38 min, p = 0.129), adenoma detection rates (25.1 vs. 35.8%, p = 0.060), percentage of patients who experienced no pain at all during the procedure (93.5 vs. 93.5%, p = 1.000), and Boston bowel preparation scores (2.23 vs. 2.34, p = 0.370).
Conclusions:
Our data suggest that on-demand sedation colonoscopy can be performed in patients, with a significant decrease in time spent in the recovery room prior to discharge. Cecal intubation time, adenoma detection rates, and percentage of patients experiencing no pain at all during the procedure were similar in both groups of patients.
More Related Videos
07:54Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
03:43Structured Approach to Colonoscopy Technique Optimization: A Single-Center Experience with Novice Endoscopists
Published on: July 11, 2025
Related Concept Videos
01:25Endoscopic Procedures II: Colonoscopy
01:26Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
01:23Sedatives and Hypnotics: Overview
Sedative-hypnotics are categorized into barbiturates, benzodiazepines (BZDs), and non-benzodiazepines or Z-drugs. These drugs work by suppressing central nervous system activity, and this suppression is dose-dependent. Older sedative medications, like barbiturates, follow a linear curve in...
01:22Stages of General Anesthesia
01:24General Anesthesia: Overview
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
01:17Sedatives and Hypnotics Drugs: Miscellaneous Agents
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...