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Updated: Nov 17, 2025

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Large-Scale SARS-CoV-2 Testing Utilizing Saliva and Transposition Sample Pooling
Published on: June 23, 2022
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A Discrete Event Simulation-Based Model to Optimally Design and Dimension Mobile COVID-19 Saliva-Based Testing
Michael Saidani1, Harrison Kim
1From the Enterprise Systems Optimization Lab, Department of Industrial and Enterprise Systems Engineering, University of Illinois at Urbana-Champaign, Champaign, IL.
Summary
This study presents a discrete event simulation model for optimizing mobile COVID-19 testing stations. The model efficiently processes 10,000 daily samples, offering adaptable solutions for public health resource allocation.
Area of Science:
- Public Health
- Epidemiology
- Operations Research
Background:
- Effective COVID-19 testing strategies are crucial for controlling viral spread.
- Mobile testing stations require efficient design and resource allocation for rapid results.
- On-campus testing presents unique logistical challenges for large populations.
Purpose of the Study:
- To address the challenge of optimal design and resource allocation for mobile COVID-19 testing stations.
- To ensure the delivery of rapid testing results to individuals.
- To develop a reusable simulation model for public health decision-making.
Main Methods:
- Development of a novel discrete event simulation model.
- Application of the model to on-campus saliva-based COVID-19 testing stations.
- Analysis of processing capacity for 10,000 samples per day using noninvasive polymerase chain reaction tests.
Main Results:
- Demonstrated the feasibility of processing 10,000 COVID-19 samples daily.
- Identified optimal configurations for mobile testing station design and resource allocation.
- Validated the model's effectiveness in a real-world university setting.
Conclusions:
- The developed discrete event simulation model provides a robust framework for optimizing mobile testing operations.
- Lessons learned offer practical insights for site managers and decision-makers in public health.
- The model's adaptability allows for application in diverse testing scenarios and contexts.

