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Updated: Nov 17, 2025

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
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Published on: May 21, 2015

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Gatekeepers of the fetus: Characterization of placental macrophages

Christina Megli1,2, Carolyn B Coyne2,3,4

  • 1Division of Maternal-Fetal Medicine, Gynecology and Reproductive Sciences, University of Pittsburgh Medical Center, Pittsburgh, PA.

The Journal of Experimental Medicine
|February 18, 2021
PubMed

In this issue of JEM, Thomas et al. (https://doi.org/10.1084/jem.20200891) provide elegant technological and conceptual advances that further our understanding of the immune cells enriched at the maternal-fetal interface. Using new isolation strategies to better separate maternal- and fetal-derived cells, the authors identify previously undefined maternal-derived immune cells associated with the fetal-derived placenta and provide an in-depth analysis of the markers and characteristics of placental Hofbauer cells.

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