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Human Blood-Brain Barrier on a Chip: Featuring Unique Multicellular Cooperation in Pathophysiology
1George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA; Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA; Mepsgenlab Inc., Atlanta, GA 30309, USA.
Trends in Biotechnology
|February 19, 2021
Abstract:
Advances in stem cell engineering have opened new avenues for more accurately developing in vitro models of the human blood-brain barrier (BBB). Here, we highlight state-of-the-art human BBB-on-a-chip technologies and discuss the importance of human brain cells for better modeling the human brain pathophysiology.
