Related Experiment Video

Updated: Nov 17, 2025

Monitoring GPCR-β-arrestin1/2 Interactions in Real Time Living Systems to Accelerate Drug Discovery
08:21

Monitoring GPCR-β-arrestin1/2 Interactions in Real Time Living Systems to Accelerate Drug Discovery

Published on: June 28, 2019

7.1K

A versatile GPCR toolkit to track in vivo neuromodulation: not a one-size-fits-all sensor

Marie A Labouesse1,2,3, Tommaso Patriarchi4,5

  • 1Department of Psychiatry, College of Physicians and Surgeons, Columbia University, Columbia, NY, USA.

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
|February 19, 2021
PubMed
Abstract

No abstract available in PubMed .

More Related Videos

Visualizing Protein Kinase A Activity In Head-fixed Behaving Mice Using In Vivo Two-photon Fluorescence Lifetime Imaging Microscopy
10:41

Visualizing Protein Kinase A Activity In Head-fixed Behaving Mice Using In Vivo Two-photon Fluorescence Lifetime Imaging Microscopy

Published on: June 7, 2019

8.8K
Ex Vivo Optogenetic Dissection of Fear Circuits in Brain Slices
11:13

Ex Vivo Optogenetic Dissection of Fear Circuits in Brain Slices

Published on: April 5, 2016

16.4K

Related Experiment Videos

Last Updated: Nov 17, 2025

Monitoring GPCR-β-arrestin1/2 Interactions in Real Time Living Systems to Accelerate Drug Discovery
08:21

Monitoring GPCR-β-arrestin1/2 Interactions in Real Time Living Systems to Accelerate Drug Discovery

Published on: June 28, 2019

7.1K
Visualizing Protein Kinase A Activity In Head-fixed Behaving Mice Using In Vivo Two-photon Fluorescence Lifetime Imaging Microscopy
10:41

Visualizing Protein Kinase A Activity In Head-fixed Behaving Mice Using In Vivo Two-photon Fluorescence Lifetime Imaging Microscopy

Published on: June 7, 2019

8.8K
Ex Vivo Optogenetic Dissection of Fear Circuits in Brain Slices
11:13

Ex Vivo Optogenetic Dissection of Fear Circuits in Brain Slices

Published on: April 5, 2016

16.4K

Related Concept Videos

GPCRs Regulate Adenylyl Cylase Activity01:09

GPCRs Regulate Adenylyl Cylase Activity

6.4K
Some GPCRs transmit signals through adenylyl cyclase (AC), a transmembrane enzyme. AC helps synthesize second messenger cyclic adenosine monophosphate (cAMP). AC catalyzes cyclization reaction and converts ATP to cAMP by releasing a pyrophosphate. The pyrophosphate is further hydrolyzed to phosphate by the enzyme pyrophosphatase, which drives cAMP synthesis to completion. However, cAMP is rapidly degraded to 5′ AMP by the enzymes phosphodiesterase (PDE), preventing overstimulation of...
6.4K
GPCR Desensitization01:12

GPCR Desensitization

7.2K
G protein-coupled receptor (GPCR) signaling plays a crucial role in cell functioning. GPCR desensitization is an equally essential process. It allows cells to respond to changing environments and regain sensitivity to new stimuli while preventing unnecessary stimulation when no longer needed. Prolonged exposure to stimuli leads to GPCR desensitization. It involves blocking the receptors from binding and activating additional G proteins. This inhibits activation of downstream effectors, thereby...
7.2K

Articles linked to this work by shared authors, journal, and citation graph.

Norepinephrine and dopamine sensor crosstalk depends on local innervation density.

Nature neuroscience·2026

The nucleus accumbens shell regulates hedonic feeding via a rostral hotspot.

eLife·2026

Monocyte-derived macrophages drive neurological tissue damage through mitochondrial reactive oxygen species.

Science immunology·2026

PinkyCaMP: an mScarlet-based calcium sensor with enhanced brightness, photostability and multiplexing capabilities.

Nature methods·2026

Next-generation multicolor indicators for in vivo imaging of norepinephrine.

Nature methods·2026

Prime editing of the β1 adrenoceptor in the brain restores physiological REM sleep in a mouse model of Alzheimer's disease.

Nature communications·2025

The role of BDNF promoter VI in mediating protective effects of prophylactic (R,S)-ketamine.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2026

A transient mitochondrial switch underlies long lasting effects of adolescent cannabis.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2026

Lithium as a therapeutic strategy for SNAP25 encephalopathies via modulation of homeostatic plasticity.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2026

Effects of prefrontal transcranial direct current stimulation on open-label placebo responses.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2026

Associations among mediodorsal thalamic-ventrolateral prefrontal cortical white matter fiber dispersion and OCD-related incompleteness.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2026

Anabolic androgenic steroids induce distinct monoaminergic and lipidomic alterations in the male rat brain.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2026

Integrating neural decoding, memristive materials, and adaptive control frameworks for next-generation hippocampal memory prosthetics.

iScience·2026

Technology and Obesity: A Year in Review.

Advances in therapy·2026

Multi-signal gate-array OFET platform for reliable D-Dimer quantification in complex biofluids.

Talanta·2026

Wafer-scale SOT-MRAM for analog crossbar array applications.

Science advances·2026

Photo-activated digital resistive switching in a cryogenic photomemory.

Nature communications·2026

An integrated protein detection platform based on "lock-and-cage" sensors and digital microfluidics.

Biosensors & bioelectronics·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies
Jove
Visualize
Contact Us