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MNI SISCOM: an Open-Source Tool for Computing Subtraction Ictal Single-Photon Emission CT Coregistered to MRI
Jeremy T Moreau1,2, Christine Saint-Martin3, Sylvain Baillet4
1McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC, Canada. jeremy.moreau@mail.mcgill.ca.
A new free software, MNI SISCOM, simplifies the analysis of epilepsy seizure onset zones using subtraction ictal single-photon emission computed tomography (SPECT) coregistered to MRI (SISCOM) images.
Area of Science:
- Neuroimaging
- Medical Software Development
Background:
- Subtraction ictal single-photon emission computed tomography (SPECT) coregistered to MRI (SISCOM) is crucial for identifying the seizure onset zone in drug-resistant epilepsy.
- Existing methods for SISCOM analysis lack user-friendly, free, and open-source software solutions.
Purpose of the Study:
- To develop a simple, graphical desktop application for computing SISCOM analysis.
- To provide accessible tools for quantitative analysis of ictal and interictal SPECT images.
Main Methods:
- Development of MNI SISCOM, a free and open-source graphical desktop application.
- Implementation of user-friendly interface for minimal user interaction.
- Inclusion of command line and Python interfaces for advanced integration.
Main Results:
- MNI SISCOM enables easy computation of SISCOM results from raw SPECT and MRI data.
- The software produces practical MRI/SPECT/SISCOM image panels for review and reporting.
- Provides both graphical and programmatic access to SISCOM computation.
Conclusions:
- MNI SISCOM offers a user-friendly, free, and open-source solution for SISCOM analysis.
- Facilitates the identification of the seizure onset zone in epilepsy patients.
- Supports integration into existing neuroimaging workflows.
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