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Protein Complex Assembly

Protein Complex Assembly

Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types. Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...

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Updated: Nov 16, 2025

Automated Robotic Liquid Handling Assembly of Modular DNA Devices

Automated Robotic Liquid Handling Assembly of Modular DNA Devices

Published on: December 1, 2017

DNA-Guided Programmable Protein Assemblies for Biomedical Applications.

Xuemei Xu¹, Da Han¹

¹Institute of Molecular Medicine and Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, State Key Laboratory of Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, P. R. China.

|February 19, 2021

Summary

This summary is machine-generated.

DNA nanotechnology enables precise construction of protein assemblies for biomedical applications like sensing and enzymatic regulation, advancing research in nanomedicine.

Keywords:

DNA drug delivery nanostructures proteins therapeutics

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Last Updated: Nov 16, 2025

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Folding and Characterization of a Bio-responsive Robot from DNA Origami

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Area of Science:

Biotechnology
Nanomedicine
Molecular Biology

Background:

Protein assemblies are crucial in biological systems.
Reconstructing protein assemblies offers significant biomedical applications, including enzymatic reaction regulation and sensing.
DNA nanotechnology provides a precise, programmable method for fabricating nanostructures.

Purpose of the Study:

To review recent advancements in programmable protein assemblies built on DNA nanoplatforms.
To discuss the future potential of DNA-guided protein assemblies in biomedical research.

Main Methods:

Utilizing DNA nanotechnology for the precise construction of protein assemblies.
Integrating proteins with diverse functions onto DNA nanostructures.
Summarizing recent research and developments in the field.

Main Results:

Demonstrated the capability of DNA nanotechnology to guide the accurate assembly of proteins.
Highlighted the successful application of these assemblies in various biomedical contexts.
Showcased the programmability and precision offered by DNA-guided approaches.

Conclusions:

DNA-guided protein assemblies represent a powerful tool for advancing biomedical research.
The precise control offered by DNA nanotechnology opens new avenues for nanomedicine and biosensing.
Continued development in this area promises significant future innovations in healthcare and diagnostics.