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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
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Cognitive dysfunction in young subjects with periodontal disease
Simona I Hategan1, Sabrina A Kamer2, Ronald G Craig3
1Department of Prosthodontics, Faculty of Dentistry, University of Medicine and Pharmacy "Victor Babes" Timisoara, Bd. Revolutiei 1989, Nr.9, 300070, Timisoara, Romania.
Summary
Young adults with aggressive periodontal disease show impaired cognitive function, particularly in memory recall. Salivary Interleukin-1 beta (IL-1β) levels may be linked to immediate cognitive scores in these individuals.
Area of Science:
- Oral health research
- Neuroscience
- Immunology
Background:
- Periodontal disease is a common inflammatory condition linked to dysbiosis.
- Previous studies suggest a correlation between periodontal disease in the elderly and cognitive decline, including Alzheimer's disease.
Purpose of the Study:
- To assess cognitive function in young adults with varying degrees of periodontal disease.
- To investigate the relationship between salivary cytokine levels (IL-1β, TNF-α) and cognitive performance.
Main Methods:
- A cross-sectional study involving 40 subjects from western Romania, categorized into aggressive periodontitis (AGG_P), chronic mild-moderate periodontitis (CR_P), and no periodontitis (NL_P) groups.
- Neuropsychological assessments included RAVLT, MOCA, MMSE, and Prague tests.
- Salivary levels of IL-1β and TNF-α were measured using ELISA.
Main Results:
- Subjects with aggressive periodontitis (AGG_P) exhibited lower scores on delayed recall for the Rey Auditory Verbal Learning Test (RAVLT) and Montreal Cognitive Assessment (MOCA) compared to the no periodontitis (NL_P) and chronic periodontitis (CR_P) groups.
- The learning curve analysis indicated reduced learning performance in the AGG_P group.
- Salivary IL-1β levels correlated with immediate cognitive scores, but not with delayed recall.
Conclusions:
- This study provides the first evidence of cognitive dysfunction in young adults with aggressive periodontitis.
- Salivary IL-1β may play a role in the observed cognitive impairments.
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