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Ossifying Plexiform Tumor: A Case Report
Sean K Lau1, Stephen S Koh1, David S Cassarino2
1Department of Pathology, Orange County-Anaheim Medical Center, Southern California Permanente Medical Group, Anaheim, CA; and.
The American Journal of Dermatopathology
|February 19, 2021
Summary
Ossifying plexiform tumor, a rare skin neoplasm, was analyzed in a 69-year-old man. This case highlights SATB2 expression, suggesting potential osteoblastic differentiation in this unique tumor.
Area of Science:
- Dermatopathology
- Skeletal Biology
Background:
- Ossifying plexiform tumor (OPT) is an exceptionally rare cutaneous neoplasm.
- Characterized by a dermal lesion with spindled/epithelioid cells, myxoid matrix, plexiform architecture, and ossification.
Observation:
- Presents a case of OPT on the lower extremity of a 69-year-old male.
- The lesion displayed characteristic morphologic features of OPT.
- Immunohistochemistry revealed diffuse SATB2 positivity, with negativity for most other markers.
Findings:
- The tumor exhibited typical histological features of ossifying plexiform tumor.
- SATB2 (Special AT-rich sequence-binding protein 2) was diffusely positive.
- No recurrence was observed post-excision.
Implications:
- This case expands the limited clinicopathologic data on ossifying plexiform tumor.
- SATB2 expression suggests a possible osteoblastic differentiation pathway for OPT.
- Further research into the histogenesis of this rare tumor is warranted.
