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Ossifying Plexiform Tumor: A Case Report.

Sean K Lau¹, Stephen S Koh¹, David S Cassarino²

¹Department of Pathology, Orange County-Anaheim Medical Center, Southern California Permanente Medical Group, Anaheim, CA; and.

The American Journal of Dermatopathology

|February 19, 2021

Summary

This summary is machine-generated.

Ossifying plexiform tumor, a rare skin neoplasm, was analyzed in a 69-year-old man. This case highlights SATB2 expression, suggesting potential osteoblastic differentiation in this unique tumor.

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Area of Science:

Dermatopathology
Skeletal Biology

Background:

Ossifying plexiform tumor (OPT) is an exceptionally rare cutaneous neoplasm.
Characterized by a dermal lesion with spindled/epithelioid cells, myxoid matrix, plexiform architecture, and ossification.

Observation:

Presents a case of OPT on the lower extremity of a 69-year-old male.
The lesion displayed characteristic morphologic features of OPT.
Immunohistochemistry revealed diffuse SATB2 positivity, with negativity for most other markers.

Findings:

The tumor exhibited typical histological features of ossifying plexiform tumor.
SATB2 (Special AT-rich sequence-binding protein 2) was diffusely positive.
No recurrence was observed post-excision.

Implications:

This case expands the limited clinicopathologic data on ossifying plexiform tumor.
SATB2 expression suggests a possible osteoblastic differentiation pathway for OPT.
Further research into the histogenesis of this rare tumor is warranted.