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Long-term Continuous EEG Monitoring in Small Rodent Models of Human Disease Using the Epoch Wireless Transmitter System
Published on: July 21, 2015
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COVID-19 Continuous-EEG Case Series: A Descriptive Study.
Saman Zafar1, Seyhmus Aydemir1, Steve Karceski1
1Department of Neurology, Weill-Cornell Medicine, New York, New York, U.S.A.; and.
Summary
This study found that while COVID-19 can cause neurological issues, seizures and status epilepticus were secondary to other medical conditions, not direct symptoms of the virus. Most patients showed nonspecific encephalopathy on EEG.
Area of Science:
- Neurology
- Infectious Diseases
- Neurophysiology
Background:
- Coronavirus disease 2019 (COVID-19), caused by SARS-CoV2, primarily affects the respiratory system but exhibits neurotropic features.
- Neurological manifestations of COVID-19 include cerebrovascular disease, myopathy, meningitis, encephalitis, demyelination, and seizures.
- Understanding the specific electroencephalographic (EEG) patterns associated with COVID-19 is crucial for patient management.
Purpose of the Study:
- To analyze continuous video-electroencephalography (EEG) findings in patients with COVID-19.
- To identify specific EEG features or epileptogenicity related to SARS-CoV2 infection.
Main Methods:
- Review of continuous video-EEG tracings from SARS-CoV2-positive patients over a two-week period.
- Analysis of patient demographics, clinical characteristics, imaging, and EEG features.
Main Results:
- Sixteen COVID-19 positive patients were included in the analysis.
- Continuous video-EEG was primarily ordered for altered mental status (11 patients) and clinical seizures (5 patients).
- Seizures and status epilepticus were not presenting symptoms but resulted from COVID-19-related complications like anoxic brain injury, stroke, lithium toxicity, hypertension, and renal disease.
Conclusions:
- Most COVID-19 patients monitored with continuous video-EEG exhibited nonspecific encephalopathy.
- Clinical seizures and electrographic status epilepticus were observed as secondary neurological complications in this patient cohort.
