Related Experiment Video
Updated: Nov 16, 2025
12:59
Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
Published on: September 26, 2013
35.0K
Interleukin-17A Interweaves the Skeletal and Immune Systems
Mengjia Tang1, Lingyun Lu2, Xijie Yu1
1Department of Endocrinology and Metabolism, Laboratory of Endocrinology and Metabolism, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.
Frontiers in Immunology
|February 22, 2021
Summary
Interleukin-17A (IL-17A) is a key cytokine influencing bone health. This review explores IL-17A's dual role in bone metabolism and its implications for immune-mediated bone diseases.
Area of Science:
- Immunology
- Skeletal Biology
- Rheumatology
Background:
- The immune and skeletal systems exhibit complex crosstalk crucial for maintaining bone homeostasis.
- Interleukin-17A (IL-17A), produced by immune cells like Th17 cells, is a significant cytokine involved in this interaction.
Purpose of the Study:
- To review the pathophysiological roles of IL-17A in skeletal homeostasis.
- To discuss the potential therapeutic strategies targeting IL-17A in immune-mediated bone diseases.
Main Methods:
- Literature review summarizing existing research on IL-17A and bone metabolism.
- Analysis of IL-17A's effects on osteoclasts and osteoblasts.
- Examination of IL-17A's involvement in various immune-mediated bone diseases.
Main Results:
- IL-17A exerts direct and indirect effects on osteoclasts, with a dual role influenced by concentration and interacting factors.
- IL-17A also demonstrates a dual role in osteoblasts in vitro.
- IL-17A is implicated as a bone-destructive cytokine in conditions such as postmenopausal osteoporosis, rheumatoid arthritis, psoriatic arthritis, and axial spondylarthritis.
Conclusions:
- IL-17A plays a critical, often detrimental, role in the pathogenesis of immune-mediated bone diseases.
- Understanding IL-17A's complex actions provides avenues for developing targeted therapies for skeletal disorders.
Related Concept Videos
01:24T Cell Types and Functions
1.7K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.7K
01:28Inflammatory Response
15.0K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
15.0K
01:28Cells of the Innate Immune Response
7.8K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
7.8K
01:20The JAK-STAT Signaling Pathway
10.2K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
10.2K
01:29Autoimmune Disorders
1.1K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
1.1K
01:23Cells of the Adaptive Immune Response
7.4K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
7.4K