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Progress in drug delivery system for fibrosis therapy
Lei Xing1, Xin Chang1, Lijun Shen1
1State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China.
Abstract:
Fibrosis is a necessary process in the progression of chronic disease to cirrhosis or even cancer, which is a serious disease threatening human health. Recent studies have shown that the early treatment of fibrosis is turning point and particularly important. Therefore, how to reverse fibrosis has become the focus and research hotspot in recent years. So far, the considerable progress has been made in the development of effective anti-fibrosis drugs and targeted drug delivery. Moreover, the existing research results will lay the foundation for more breakthrough delivery systems to achieve better anti-fibrosis effects. Herein, this review summaries anti-fibrosis delivery systems focused on three major organ fibrotic diseases such as liver, pulmonary, and renal fibrosis accompanied by the elaboration of relevant pathological mechanisms, which will provide inspiration and guidance for the design of fibrosis drugs and therapeutic systems in the future.
Insights
Reversing fibrosis, a key process in chronic diseases like liver, lung, and kidney conditions, is crucial. This review highlights advanced drug delivery systems for effective anti-fibrosis therapies.
Area of Science:
- Biomedical Engineering
- Pharmacology
- Pathology
Background:
- Fibrosis is a critical pathological process in chronic diseases, potentially leading to cirrhosis and cancer.
- Early intervention in fibrosis is vital for disease management and improving patient outcomes.
- Reversing fibrosis is a significant research focus, driving innovation in therapeutic strategies.
Purpose of the Study:
- To review current anti-fibrosis drug delivery systems.
- To elucidate the pathological mechanisms underlying liver, pulmonary, and renal fibrosis.
- To provide insights for future fibrosis drug and delivery system development.
Main Methods:
- Literature review of anti-fibrosis drug delivery systems.
- Analysis of pathological mechanisms in major organ fibrotic diseases.
- Synthesis of existing research for future applications.
Main Results:
- Significant progress has been made in developing effective anti-fibrosis drugs and targeted delivery systems.
- Existing research provides a foundation for next-generation delivery systems.
- Understanding pathological mechanisms is key to designing targeted therapies.
Conclusions:
- Advanced drug delivery systems are essential for effective anti-fibrosis treatments.
- This review consolidates knowledge on fibrosis mechanisms and delivery systems.
- Future research should focus on innovative delivery platforms for fibrosis reversal.
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