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Adherence to Iron Chelation Therapy and Its Determinants
Sukhmani Sidhu1, Shruti Kakkar2, Priyanka Dewan2
1Bachelor of Medicine and Bachelor of Surgery Student, Dayanand Medical College, Ludhiana, Punjab, India.
Nearly 11% of transfusion-dependent thalassemia patients show non-adherence to iron chelation therapy (ICT). This non-adherence leads to increased iron overload, highlighting the need for improved treatment strategies.
Area of Science:
- Hematology
- Pharmacology
- Public Health
Background:
- Thalassemia is a chronic condition necessitating lifelong treatment.
- Adherence to iron chelation therapy (ICT) is crucial for preventing complications and ensuring a good quality of life in transfusion-dependent thalassemia (TDT) patients.
Purpose of the Study:
- To assess adherence to ICT in TDT patients.
- To identify reasons for non-adherence.
- To evaluate the impact of non-adherence on iron overload complications.
Main Methods:
- Patients with TDT on ICT for over 6 months were enrolled.
- Hospital records were reviewed for demographic data, iron status, and complications.
- A questionnaire assessed adherence, knowledge, and reasons for non-adherence.
Main Results:
- 10.7% of TDT patients were non-adherent to ICT.
- Non-adherent patients had significantly higher serum ferritin levels and greater cardiac/liver iron overload.
- Difficulties with drug administration and polypharmacy were key reasons for non-adherence.
Conclusions:
- Approximately 11% of TDT patients are non-adherent to ICT.
- Non-adherence to ICT significantly increases iron overload in TDT patients.
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