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Pathogenic mechanisms and the potential clinical value of circFoxo3 in cancers
Lei Zhang1, Yin Wang1, Yuan Zhang1
1Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, Qingdao University, NO38 DengZhou Road, Qingdao 266021, China.
Abstract:
Circular RNAs (circRNAs) are covalently closed circular structures that can function in various physiological and pathological processes by acting as microRNA (miRNA) sponges, RNA-binding protein (RBP) sponges, mRNA transcriptional regulators, and protein translational templates. circFoxo3 is one of the most studied circRNAs and is generated from the tumor suppressor gene Foxo3. Increasing studies have demonstrated the multiple functions of circFoxo3 in the pathogenesis of different cancer types. circFoxo3 plays important roles in cancer development mainly by binding to various miRNAs. The diagnostic potential of circFoxo3 has been revealed in several cancers. Some research results have been found to contradict the results of other studies, and this may be due to insufficient sample sizes and inconsistencies in the experimental and nomenclature methods. In this review, we systematically summarize current knowledge about the biogenesis and functions of circRNAs, elucidate the roles of circFoxo3 in different cancers, and explore the clinical applications of circFoxo3.
Insights
Circular RNAs (circRNAs) are versatile molecules involved in gene regulation. This review details circFoxo3
Area of Science:
- Molecular Biology
- Genetics
- Cancer Research
Background:
- Circular RNAs (circRNAs) are unique RNA structures with diverse regulatory roles.
- circFoxo3, derived from the Foxo3 gene, is a well-studied circRNA implicated in various cancers.
- circRNAs function as miRNA sponges, RBP sponges, and regulators of transcription and translation.
Purpose of the Study:
- To systematically review the biogenesis and functions of circRNAs.
- To elucidate the specific roles of circFoxo3 in the pathogenesis of different cancer types.
- To explore the potential clinical applications and diagnostic value of circFoxo3 in oncology.
Main Methods:
- Literature review and systematic summarization of existing research on circRNAs and circFoxo3.
- Analysis of studies investigating circFoxo3's interactions with microRNAs (miRNAs) and RNA-binding proteins (RBPs).
- Evaluation of evidence regarding circFoxo3's involvement in cancer development and its diagnostic potential.
Main Results:
- circFoxo3 plays significant roles in cancer development, primarily through interactions with various miRNAs.
- The diagnostic potential of circFoxo3 has been observed in several cancer types.
- Contradictory findings in existing research may stem from small sample sizes and methodological inconsistencies.
Conclusions:
- circFoxo3 is a key player in cancer pathogenesis with potential as a diagnostic biomarker.
- Further standardized research is needed to reconcile conflicting findings and fully establish circFoxo3's clinical utility.
- Understanding circRNA biology, including circFoxo3, offers new avenues for cancer diagnosis and therapy.
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