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Amino acids profile in girls with Turner syndrome during growth hormone therapy
Jolanta Bugajska1, Joanna Berska2, Małgorzata Wójcik3
1Department of Clinical Biochemistry, Institute of Paediatrics, Jagiellonian University Medical College, Krakow, Poland. jola.bugajska@uj.edu.pl.
Introduction:
The influence of growth hormone (GH) treatment on amino acids (AAs) profile in patients with Turner syndrome (TS) was investigated.
Material And Methods:
The study group included girls with TS: treated with GH (GH+) and girls with no GH treatment (GH-). The control group consisted of healthy girls. Free plasma AAs were measured by the LC/MS/MS.
Results:
The plasma concentrations of glutamine, threonine were significantly higher in group GH+ than in group GH- (p < 0.05). In group GH- the values of glutamine, alanine, isoleucine, glutamic acid were significantly different than in the control (p < 0.05-p < 0.008).
Conclusion:
AAs profile in girls with TS might be characteristic for the disease but also depends on GH treatment.
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