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Updated: Nov 16, 2025

Femoral Arterial and Venous Catheterization for Blood Sampling, Drug Administration and Conscious Blood Pressure and Heart Rate Measurements
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Hemostatic Needles: Controlling Hemostasis Time by a Catecholamine Oxidative Pathway.

Mikyung Shin1, Jae Hyuk Choi1, Keumyeon Kim2

  • 1Department of Intelligent Precision Healthcare Convergence, SKKU Institute for Convergence, Sungkyunkwan University (SKKU), 2066 Seobu-ro, Suwon 16419, Republic of Korea.

ACS Applied Materials & Interfaces
|February 23, 2021
PubMed
Summary

This study introduces a novel self-sealing hemostatic needle using mussel-inspired chitosan-catechol. Optimized for rapid transfer, it prevents bleeding after injections, reducing secondary infection risks from infectious viruses in blood.

Keywords:
Michael additionSchiff basechitosan-catecholhemostatic needlesself-sealing

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Area of Science:

  • Biomaterials Science
  • Medical Devices
  • Infectious Disease Prevention

Background:

  • Hemorrhage in patients with infectious viruses poses a significant risk for secondary infections.
  • Existing needles can cause bleeding, potentially spreading viruses.
  • Mussel adhesive polysaccharides offer inspiration for novel hemostatic materials.

Purpose of the Study:

  • To develop and characterize a novel self-sealing hemostatic needle.
  • To investigate the mechanism of self-sealing and hemostasis.
  • To reduce the risk of secondary infections associated with bloodborne viruses.

Main Methods:

  • Fabrication of needles using chitosan-catechol inspired by mussel adhesive polysaccharides.
  • Investigation of phase transition from solid film to adhesive gel upon contact with blood.
  • Analysis of self-sealing time and hemostasis based on oxidation pathways (high-temperature vs. low-temperature).

Main Results:

  • The self-sealing needle demonstrates rapid phase transition from a thin film to an adhesive gel in blood.
  • High-temperature oxidation (60 °C) promotes Michael addition, weakening attachment and enabling efficient film transfer for complete hemostasis (<5 s).
  • Low-temperature oxidation (4 °C) favors Schiff base formation, strengthening attachment and leading to incomplete hemostasis due to poor tissue transfer.

Conclusions:

  • The developed self-sealing hemostatic needle effectively prevents bleeding post-injection.
  • Oxidation pathway significantly influences the hemostatic performance of chitosan-catechol needles.
  • This technology holds potential for safer medical procedures in patients with infectious viruses, minimizing secondary infection risks.