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Hypogelsolinemia and Decrease in Blood Plasma Sphingosine-1-Phosphate in Patients Diagnosed with Severe Acute
Tomasz Wollny1, Marzena Wątek1,2, Urszula Wnorowska3
1Holy Cross Oncology Center of Kielce, Artwińskiego 3, 25-734, Kielce, Poland.
Digestive Diseases and Sciences
|February 23, 2021
Summary
Plasma gelsolin and sphingosine-1-phosphate levels decrease in acute pancreatitis patients. Monitoring these biomarkers may improve diagnosis of severe acute pancreatitis.
Area of Science:
- Biochemistry
- Clinical Medicine
- Inflammation Research
Background:
- Acute pancreatitis (AP) is a common cause of hospitalization for gastrointestinal disorders.
- Gelsolin binds bioactive lipids, including sphingolipids involved in inflammation.
- Low gelsolin levels (hypogelsolinemia) are linked to inflammatory conditions.
Purpose of the Study:
- To investigate the relationship between plasma gelsolin and sphingosine-1-phosphate (S1P) in AP patients.
- To assess the diagnostic potential of these biomarkers in AP.
Main Methods:
- Quantified plasma gelsolin (pGSN) and S1P using immunoblotting and HPLC.
- Measured inflammatory markers: amylase, lipase, C-reactive protein (CRP), procalcitonin (PCT).
- Recorded white blood cell (WBC) and platelet (PLT) counts.
Main Results:
- AP patients showed significantly lower plasma gelsolin and S1P levels compared to controls.
- Elevated CRP, WBC, amylase, and lipase correlated with lower gelsolin levels in AP.
- No correlation was found between PCT/PLT and gelsolin levels.
Conclusions:
- Plasma gelsolin and S1P levels decrease in severe acute pancreatitis.
- Simultaneous measurement of gelsolin and S1P may enhance diagnostic strategies for AP.
- These biomarkers show potential for improved patient stratification in AP.
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